Multisynthetase complex auxiliary component p38

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Identifiers
Symbols AIMP2; JTV-1; JTV1; P38
External IDs OMIM600859 MGI2385237 HomoloGene4594 GeneCards: AIMP2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7965 231872
Ensembl ENSG00000106305 ENSMUSG00000029610
UniProt Q13155 n/a
RefSeq (mRNA) NM_006303 NM_146165
RefSeq (protein) NP_006294 NP_666277
Location (UCSC) Chr 7:
6.05 – 6.06 Mb
Chr 5:
144.66 – 144.67 Mb
PubMed search [1] [2]

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.[1][2][3]

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.[3]

Interactions

Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin (ligase),[4] P53[2] and KARS.[5][6]

References

  1. ^ Nicolaides NC, Kinzler KW, Vogelstein B (Aug 1996). "Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene". Genomics 29 (2): 329–34. doi:10.1006/geno.1995.9997. PMID 8666379. 
  2. ^ a b Han JM, Park BJ, Park SG, Oh YS, Choi SJ, Lee SW, Hwang SK, Chang SH, Cho MH, Kim S (Aug 2008). "AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53". Proc Natl Acad Sci U S A 105 (32): 11206–11. doi:10.1073/pnas.0800297105. PMC 2516205. PMID 18695251. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2516205. 
  3. ^ a b "Entrez Gene: JTV1 JTV1 gene". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7965. 
  4. ^ Corti, Olga; Hampe Cornelia, Koutnikova Hana, Darios Frédéric, Jacquier Sandrine, Prigent Annick, Robinson Jean-Charles, Pradier Laurent, Ruberg Merle, Mirande Marc, Hirsch Etienne, Rooney Thomas, Fournier Alain, Brice Alexis (Jun. 2003). "The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration". Hum. Mol. Genet. (England) 12 (12): 1427–37. doi:10.1093/hmg/ddg159. ISSN 0964-6906. PMID 12783850. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Quevillon, S; Robinson J C, Berthonneau E, Siatecka M, Mirande M (Jan. 1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". J. Mol. Biol. (ENGLAND) 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. ISSN 0022-2836. PMID 9878398. 

Further reading